The Young Investigator Draft presented by CSL Behring is the result of Uplifting Athletes’ ongoing commitment to cultivate resources that accelerate scientific advancements for rare disease treatments and potential cures while facilitating the next generation of rare disease researchers.
To learn more about the 2020 Young Investigator Draft and to purchase tickets click here.
Researcher: Dr. Jonathan Whittamore
Young Investigator Institution: University of Florida
Education: Dr. Whittamore received his Bachelor’s degree in Zoology from John Moores University in Liverpool in 2000 and completed his Master’s in Marine Biology from the University of Wales, Bangor in 2003. He obtained his PhD in comparative and integrative physiology at the University of Exeter in 2009.
Research: Dr. Whittamore’s research is centered on the Primary Hyperoxalurias, a group of rare genetic diseases that cause defects in key enzymes leading to increased oxalate production by the liver. These conditions result in persistent hyperoxaluria (elevated levels of oxalate in the urine) and, as a consequence, recurrent kidney stone formation. Progressive kidney failure ensues accompanied by severe damage to other organs from the deposition of oxalate. The goal of this project is to understand how this excess oxalate is being transported out of the liver by describing, for the first time, the cellular mechanism(s) responsible and resolving the molecular identity of the proteins involved.
In Their Words: “I didn’t set out to go into biomedical research. When I got the opportunity to go to University I was only focused on what I was interested in. I was always interested in natural history, dinosaurs, sharks etc. I always got along well with biology in school. So I went into zoology when I first went to University. In my final year I had to do a project where you had to do a research element and I absolutely loved it. That started me down a path I’m on today, but I didn’t know it at the time.” – Dr. Jonathan Whittamore
Born and raised in Derby, England, Dr. Whittamore grew up wanting to do the one thing plenty of young lads in the United Kingdom dream of – playing football (soccer) professionally.
Dr. Whittamore tells the story today about his passion for football and how it so consumed him during his teenage years that literally nothing else mattered. Including his education. In his words “school was simply something I had to do so I could play football.”
His passion and love for the game took its toll, though, and he admits his education suffered. The price he paid was steep, but when reality hit and being a professional football player was off the table, Dr. Whittamore went to work.
To say Dr. Whittamore’s path to becoming a highly respected researcher was an unconventional path is a valid statement instead of just a common phrase.
“It wasn’t by design, I can certainly tell you that,” said Dr. Whittamore, who is a naturalized citizen of the United States with a son in middle school. “When I was working on my PhD, I really had this desire to want my work to have more purpose. Up until that point I had been doing what was of interest to me. Where I am today certainly was not by design.”
His narrow focus on football only forced Dr. Whittamore to retake his A Levels – the equivalent of a high school diploma in the United Kingdom – and find a job. Since his father, and his father before him, each had long careers working for Royal Mail, Dr. Whittamore spent two years following in their footsteps.
“I worked at Royal Mail for two years, met a lot of guys who only wanted to work for Royal Mail for a couple years and 10-20 years later they are still there in the same job,” Dr. Whittamore said. “And I saw that and knew I couldn’t do that. There had to be something more for me. That was when I decided to start down my journey in science because it was what I was interested in.”
During his schooling in zoology and marine biology, it was the research part of science that most intrigued and inspired Dr. Whittamore. After seven years in the lab at Exeter obtaining his PhD, he knew it was time to look in a different direction.
He wanted to work with new people, learn new techniques and skills in the lab. After marrying an American, Dr. Whittamore knew his wife was keen on returning to the United States.
Pouring over job openings, Dr. Whittamore was intrigued by the research being conducted in the lab at the University of Florida (UF). So he blindly applied for the job based on the ad without knowing anything about the team at UF led, by now mentor, by Dr. Marguerite Hatch. Dr. Whittamore simply thought he was a good fit.
“I knew nothing of my mentor now. I applied simply based on the ad. I was drawn to the ad and captivated by it,” Dr. Whittamore said. “We use very traditional and old-school techniques, but they are still relevant today and are powerful tools to answer the questions of today. I feel strongly we are helping people and doing a lot of good.”
Dr. Whittamore was nominated for a 2020 Uplifting Athletes’ Young Investigator Draft research grant on behalf of the Oxalosis & Hyperoxaluria Foundation (OHF). The Oxalosis & Hyperoxaluria Foundation (OHF) is dedicated to finding treatments and a cure for all forms of hyperoxaluria. OHF supports thousands of healthcare professionals, patients, and their families, and we aim to share our knowledge so that everyone has accurate information about the advances in this disease. OHF is a donor-funded nonprofit, spending 90 percent of every dollar raised on research and programs for our community.